Context:

Ozempic feet, a side effect of rapid weight loss from GLP-1 medications like Ozempic, Wegovy, and Zepbound, involves sagging skin and reduced fat padding on the feet, leading to discomfort and potential changes in gait. This phenomenon can result in painful sensations akin to walking on bone due to the loss of natural shock absorbers. Experts suggest managing this by promoting slower weight loss, maintaining hydration, and wearing supportive shoes to help the skin adjust and reduce discomfort. There are broader implications as significant rapid weight loss can also affect other body areas, such as the face and hands, leading to similar skin and fat-related changes. While these effects are not exclusive to GLP-1 drugs, those with severe obesity-related conditions may experience more benefits than risks from these medications, unlike those without obesity who may not see a favorable risk-benefit ratio.

Dive Deeper:

• Ozempic feet refers to a side effect where rapid weight loss causes sagging skin and reduced fat padding on the feet, resulting in visible tendons or veins and discomfort when walking or standing.

• The rapid loss of fat, especially beneath the heel and ball of the feet, removes the natural shock absorbers, making the skin lax and unsupported, which can alter gait mechanics and exacerbate existing foot conditions.

• For those experiencing significant weight loss, gradual reduction is recommended to allow skin to adjust, alongside maintaining hydration and wearing supportive footwear to minimize discomfort and prevent skin issues.

• Rapid weight loss can have similar effects on the hands, leading to a skeletal appearance known as 'Ozempic hands,' due to visible tendons and veins, as the skin fails to contract quickly enough.

• While these side effects are not unique to GLP-1 medications, individuals with obesity-related diseases may find the benefits of these drugs outweigh the risks, contrary to those without obesity.

• Monitoring for changes in foot appearance or pain is crucial, especially for people with diabetes who are already at risk of foot-related complications, necessitating a thorough medical evaluation.

• Gradual weight loss and a supportive regimen involving healthcare professionals can help manage these side effects while addressing obesity and its related health conditions.